FMN cofactor: Complex I
- Entry point of NADH electrons into the respiratory chain
- The electron-entry flavin of Complex I (NADH → ubiquinone)
- Derived from riboflavin (vitamin B2)
- Riboflavin deficiency shows up as energy-pathway failure
Drugs with this mechanism (1)
- FMN — Riboflavin-derived redox cofactor; accepts electrons in mitochondrial complex I and other flavoprotein reactions.
Self-check
- Electrons from which donor enter the respiratory chain through FMN?
NADH. - Which vitamin supplies FMN?
Riboflavin (B2).
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