FAD cofactor: acyl-CoA dehydrogenases
- First step of each beta-oxidation cycle
- An acyl-CoA dehydrogenase hands the electrons to FAD (→ ETF → chain)
- Riboflavin responds in some fatty-acid-oxidation disorders
Drugs with this mechanism (1)
- FAD — Riboflavin-derived redox cofactor; transfers electrons in fatty-acid oxidation and mitochondrial energy production.
Self-check
- At what point in beta-oxidation do acyl-CoA dehydrogenases act?
The first step of each cycle. - Where do electrons go after FAD in this pathway?
ETF, then the respiratory chain.
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