FAD cofactor: MAO
- Required for degradation of dopamine, norepinephrine and serotonin
- Monoamine oxidase is a flavoprotein: FAD accepts the electrons
- The flavin is the site attacked by irreversible MAO inhibitors
Drugs with this mechanism (1)
- FAD — Riboflavin-derived redox cofactor; transfers electrons in fatty-acid oxidation and mitochondrial energy production.
Self-check
- What does FAD accept during MAO-catalyzed deamination?
Electrons. - Which part of MAO is attacked by irreversible inhibitors?
The flavin.
All mechanisms · Open FAD cofactor: MAO in the interactive console ↗