FAD cofactor: Complex II
- Links the TCA cycle directly to the electron-transport chain
- FAD is covalently wired into succinate dehydrogenase
- Derived from riboflavin (vitamin B2)
Drugs with this mechanism (1)
- FAD — Riboflavin-derived redox cofactor; transfers electrons in fatty-acid oxidation and mitochondrial energy production.
Self-check
- Which enzyme has covalently bound FAD linking the TCA cycle and respiratory chain?
Succinate dehydrogenase. - Which vitamin supplies FAD?
Riboflavin (B2).
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