Clotting-factor repletion (4F-PCC)

Replaces the vitamin-K-dependent factors NOW, not in 6 hours

Concentrated factors II, VII, IX, X (+ proteins C/S) — reverses warfarin in minutes
Beats FFP: 25× smaller volume, no thawing, faster INR correction
➔ prothrombin complex concentrate, 4-factor (KCENTRA)
Give IV vitamin K with it or the INR rebounds as the factors decay
Thrombosis is the tradeoff — the label carries that warning boxed ⚠

Drugs with this mechanism (1)

Prothrombin complex concentrate (4-factor) — Concentrated clotting-factor replacement for rapid warfarin reversal; thrombosis is the tradeoff.

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