Ergosterol pore former
Ergosterol-binding pore former
- Cell contents leak → fungicidal
- Broadest antifungal spectrum
- Partial cholesterol affinity explains the renal and infusion toxicity
Drugs with this mechanism (2)
- Amphotericin B — Broad-spectrum antifungal; severe infusion and renal toxicity ("ampho-terrible").
- Nystatin — Topical/oral polyene antifungal for candidiasis; not absorbed.
Self-check
- Why are ergosterol-binding pore formers fungicidal?
Cell contents leak out. - What off-target affinity helps explain their renal and infusion toxicity?
Partial cholesterol affinity.
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