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ERβ antagonist

• Blocks ERβ — removes its antiproliferative, ERα-counterbalancing tone

Drugs with this mechanism (3)

• Clomiphene — Estrogen-receptor modulator that induces ovulation.
• Endoxifen — Tamoxifen's potent active metabolite — made by CYP2D6, which is why 2D6 inhibitors matter in breast cancer.
• Raloxifene — SERM that protects bone and lowers breast-cancer risk without stimulating the uterus.

All mechanisms · Open the interactive console ↗