TPO inhibitor
Thyroid peroxidase inhibitor
- No iodination or coupling → ↓ hormone synthesis
- Treats hyperthyroidism
- Onset awaits depletion of stored hormone
- Agranulocytosis and hepatotoxicity are the class dangers
Drugs with this mechanism (2)
- Methimazole — First-line thyroid peroxidase inhibitor for hyperthyroidism.
- Propylthiouracil — Antithyroid drug preferred in first-trimester pregnancy; hepatotoxic.
Self-check
- Why is TPO-inhibitor onset delayed?
Stored thyroid hormone must be depleted. - Which serious blood-cell toxicity can TPO inhibitors cause?
Agranulocytosis.
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