SYK inhibitor

Spleen tyrosine kinase (SYK) inhibitor

Blocks spleen tyrosine kinase (SYK) downstream of Fc receptors
Macrophages stop destroying antibody-coated platelets → treats refractory ITP
Hypertension and diarrhea are the common mechanism-linked effects

Drugs with this mechanism (1)

Fostamatinib — Prodrug of the SYK inhibitor R406 for chronic immune thrombocytopenia; diarrhea, hypertension, and liver-enzyme elevations.

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