ROCK inhibitor
Rho kinase inhibitor
- Trabecular meshwork relaxes
- ↑ conventional aqueous outflow → ↓ intraocular pressure
- Used in glaucoma
- Vasodilation → conjunctival hyperemia
Drugs with this mechanism (1)
- Netarsudil — Rho kinase inhibitor that increases trabecular outflow; conjunctival hyperemia is common.
Self-check
- Which aqueous outflow route increases with ROCK inhibition?
Conventional trabecular outflow. - What vascular effect explains conjunctival hyperemia with ROCK inhibitors?
Vasodilation.
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