Ribonucleotide reductase inhibitor
- Deoxyribonucleotides run out
- DNA synthesis stalls in rapidly dividing cells
- Myelosuppression
- Raises fetal hemoglobin → ↓ sickling
Drugs with this mechanism (1)
- Hydroxyurea — Ribonucleotide reductase inhibitor; raises fetal hemoglobin in sickle cell disease.
Self-check
- Which hemoglobin rises with ribonucleotide-reductase inhibition in sickle-cell disease?
Fetal hemoglobin. - Which nucleotides become depleted when ribonucleotide reductase is inhibited?
Deoxyribonucleotides.
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