MurA inhibitor
- Blocks the first committed step of bacterial peptidoglycan synthesis
- Example: fosfomycin
- A unique target with minimal cross-resistance
Drugs with this mechanism (1)
- Fosfomycin — Single-dose oral agent for uncomplicated UTIs, including resistant organisms.
Self-check
- Which antibiotic inhibits MurA?
Fosfomycin. - Which stage of peptidoglycan synthesis does MurA inhibition block?
The first committed step.
All mechanisms · Open MurA inhibitor in the interactive console ↗