MEK inhibitor
- MEK (mitogen-activated protein kinase kinase) lies downstream of RAF
- Suppresses MAPK-pathway tumors
- Pairs with BRAF inhibitors
- Ocular (serous retinopathy) and cardiac (↓ EF) monitoring are class standards
Drugs with this mechanism (1)
- Trametinib — MEK inhibitor usually paired with a BRAF inhibitor to delay resistance.
Self-check
- Which inhibitor class is paired with MEK inhibitors?
BRAF inhibitors. - Which cardiac measure can fall during MEK inhibition?
Ejection fraction.
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