IMPDH inhibitor
Inosine monophosphate dehydrogenase inhibitor
- ↓ guanine nucleotide synthesis
- Lymphocytes depend on this de novo route → selective immunosuppression
- GI toxicity and teratogenicity are the practical limits
- Cytopenias
Drugs with this mechanism (1)
- Mycophenolate mofetil — IMPDH inhibitor that starves lymphocytes of guanosine; teratogenic.
Self-check
- Which nucleotide synthesis falls with IMPDH inhibition?
Guanine nucleotide synthesis. - Why are lymphocytes selectively affected by IMPDH inhibition?
They depend on the de novo pathway.
All mechanisms · Open IMPDH inhibitor in the interactive console ↗