Ile-tRNA synthetase inhibitor
Isoleucyl-tRNA synthetase inhibitor
- Bacterial protein synthesis fails
- Eradication of staphylococci, including nasal MRSA carriage (topical)
- A target unused by any systemic antibiotic — no cross-resistance
Drugs with this mechanism (1)
- Mupirocin — Topical isoleucyl-tRNA synthetase inhibitor for impetigo and MRSA decolonization.
Self-check
- Which nasal carriage can topical isoleucyl-tRNA synthetase inhibition eradicate?
MRSA carriage. - Which bacterial process fails after this target is inhibited?
Protein synthesis.
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