HIF-PH inhibitor
HIF prolyl hydroxylase inhibitor
- HIF is no longer degraded
- Stabilized HIF drives erythropoietin production → treats renal anemia
- Taken orally
- Pharmacologic altitude — thrombosis and tumor-growth theoretical concerns follow the same biology
Drugs with this mechanism (2)
- Roxadustat — Oral HIF-prolyl-hydroxylase inhibitor for CKD anemia in some countries; stimulates erythropoiesis, with thrombotic concerns.
- Vadadustat — Oral HIF prolyl-hydroxylase inhibitor for anemia of CKD in adults receiving dialysis.
Self-check
- Which hormone production rises when HIF is stabilized?
Erythropoietin. - Is the tumor-growth concern described here established or theoretical?
Theoretical.
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