DPP-4 inhibitor
Dipeptidyl peptidase-4 inhibitor
- Incretins (GLP-1, GIP) survive longer
- Glucose-dependent ↑ insulin and ↓ glucagon — low hypoglycemia risk
- Weight-neutral
- Rare pancreatitis and bullous pemphigoid reports
- Joint pain
Drugs with this mechanism (5)
- Alogliptin — DPP-4 inhibitor for type 2 diabetes; weight-neutral but carries a heart-failure warning.
- Gemigliptin — DPP-4 inhibitor used for type 2 diabetes in some countries; weight-neutral with low hypoglycemia risk when used alone.
- Linagliptin — DPP-4 inhibitor for diabetes; uniquely non-renally cleared, no dose adjustment.
- Saxagliptin — DPP-4 inhibitor for diabetes; uniquely burdened by a heart-failure signal.
- Sitagliptin — The first DPP-4 inhibitor; weight-neutral, well tolerated.
Self-check
- Why is hypoglycemia risk low with DPP-4 inhibition?
Its insulin/glucagon effects are glucose-dependent. - How does DPP-4 inhibition affect weight?
Weight-neutral.
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