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COMT inhibitor

• Prevents peripheral levodopa breakdown — smoother dopamine delivery

Drugs with this mechanism (3)

• Entacapone — Peripheral COMT inhibitor extending levodopa; turns urine orange.
• Opicapone — Long-acting COMT inhibitor for Parkinson wearing-off; low pill burden and no hepatotoxicity signal.
• Tolcapone — The COMT inhibitor that crosses into brain - and carries a boxed hepatotoxicity warning.

All mechanisms · Open the interactive console ↗