ALDH inhibitor
Aldehyde dehydrogenase inhibitor
- Acetaldehyde accumulates when alcohol is consumed
- Flushing, nausea, tachycardia — aversive alcohol reaction
Drugs with this mechanism (1)
- Disulfiram — Aldehyde-dehydrogenase inhibitor causing an aversive reaction to alcohol.
Self-check
- What accumulates after alcohol during aldehyde-dehydrogenase inhibition?
Acetaldehyde. - Which three symptoms characterize the aversive alcohol reaction here?
Flushing, nausea and tachycardia.
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