AADC inhibitor
Aromatic L-amino acid decarboxylase inhibitor
- Levodopa is not converted to dopamine outside the brain
- More levodopa reaches the CNS
- Peripheral dopamine nausea falls
Drugs with this mechanism (1)
- Carbidopa — Peripheral AADC inhibitor given with levodopa to boost CNS delivery.
Self-check
- Why does peripheral AADC inhibition increase levodopa delivery to the brain?
It prevents peripheral conversion to dopamine. - Which peripheral dopamine adverse effect falls with AADC inhibition?
Nausea.
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