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AADC inhibitor

• Blocks peripheral levodopa decarboxylation
• Allows more levodopa to reach the brain and reduces nausea

Drugs with this mechanism (4)

• Carbidopa — Peripheral AADC inhibitor given with levodopa to boost CNS delivery.
• Carbidopa/ levodopa — Core dopamine replacement for Parkinson disease; motor fluctuations emerge over time.
• Carbidopa/ levodopa enteral — Continuous intestinal carbidopa–levodopa gel for advanced Parkinson motor fluctuations.
• Carbidopa/ levodopa ER — Extended-release carbidopa–levodopa capsules for Parkinson motor fluctuations.

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