3CL protease inhibitor
- Prevents polyprotein cleavage → halts SARS-CoV-2 replication
Drugs with this mechanism (1)
- Nirmatrelvir — The COVID protease inhibitor in Paxlovid; boosted by ritonavir.
Self-check
- Which viral processing step does 3CL inhibition prevent?
Polyprotein cleavage. - Which PAXLOVID component inhibits 3CL protease?
Nirmatrelvir.
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