Adenosine reuptake inhibitor

Adenosine reuptake inhibitor (equilibrative nucleoside transporter blocker)

Inhibits Equilibrative Nucleoside Transporter (ENT)
Blocks adenosine reuptake into red blood cells and endothelial cells → vasodilation and antiplatelet effects
➔ for stroke prevention
➔ used in cardiac stress testing
➔ adenosine-mediated side effects ◇ dyspnea, bradyarrhythmias

Drugs with this mechanism (3)

Cannabidiol — Purified, nonintoxicating cannabinoid for severe developmental epilepsies.
Dipyridamole — Antiplatelet vasodilator; used with aspirin and for cardiac stress testing.
Ticagrelor — Reversible P2Y12 antiplatelet; twice-daily, causes dyspnea.

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