DNA cross-linker
DNA cross-linking agent
- Blocks replication and transcription
- Platinum agents cross-link DNA strands
- Broadly cytotoxic to dividing tumor cells
- Myelosuppression
- Nephrotoxicity, ototoxicity, severe emesis
Drugs with this mechanism (1)
- Cisplatin — Platinum DNA-crosslinking chemotherapy; nephro-, oto-, and neurotoxic.
Self-check
- Which metal-based agents cross-link DNA strands?
Platinum agents. - Which sensory organ toxicity accompanies platinum DNA cross-linking?
Ototoxicity.
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