DHFR inhibitor

Dihydrofolate reductase inhibitor

Blocks folate reduction — impaired DNA synthesis
Myelosuppression, mucositis, hepatotoxicity
Reversed by supplying reduced folate

Drugs with this mechanism (1)

Methotrexate — Antifolate; low-dose anchor DMARD for rheumatoid arthritis, high-dose chemotherapy.

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