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D1 glutamate modulator

• Theorized mechanism:
• ➔ D1 and NMDA receptors are co-localized on dendritic spines of cortical pyramidal neurons ◇ may form functional receptor complexes
• ➔ D1 activation triggers intracellular signaling cascades (e.g., cAMP/ Protein Kinase A pathways)
• ➔ these cascades increase phosphorylation of nearby NMDA receptor subunits
• ➔ phosphorylated NMDA receptors exhibit enhanced synaptic function

Drugs with this mechanism (1)

• Lumateperone — Low-metabolic-burden atypical for schizophrenia and bipolar depression; sedation dominates.

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