Cytochrome bc1 inhibitor
Mitochondrial cytochrome bc1 inhibitor
- Collapses protozoal and fungal mitochondrial electron transport
- ↓ pyrimidine synthesis in Plasmodium (DHODH depends on electron transport)
- Kills Plasmodium and Pneumocystis
Drugs with this mechanism (1)
- Atovaquone — Blocks protozoal mitochondrial electron transport; absorption needs fatty food.
Self-check
- Which Plasmodium synthesis pathway falls when electron transport is blocked?
Pyrimidine synthesis. - Which organisms are killed by cytochrome bc1 inhibition here?
Plasmodium and Pneumocystis.
All mechanisms · Open Cytochrome bc1 inhibitor in the interactive console ↗