CysLT1 antagonist
Cysteinyl leukotriene receptor antagonist
- ↓ bronchoconstriction, mucus and allergic inflammation
- Asthma and allergic rhinitis
- Neuropsychiatric events: agitation, depression, sleep disturbance, suicidality
Drugs with this mechanism (2)
- Montelukast — Leukotriene antagonist for asthma and allergy; neuropsychiatric warning.
- Zafirlukast — Leukotriene receptor antagonist; a 2C9 inhibitor, unlike montelukast.
Self-check
- How does CysLT1 blockade affect bronchoconstriction?
Reduces it. - What serious psychiatric event is included in this mechanism's warning list?
Suicidality.
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