CRF1 antagonist
Corticotropin-releasing factor 1 receptor antagonist
- ↓ pituitary ACTH drive → lets congenital adrenal hyperplasia be controlled with physiologic steroid doses
- Treats the axis, not the enzyme defect
Drugs with this mechanism (1)
- Crinecerfont — CRF1 antagonist; reduces ACTH-driven androgen excess in congenital adrenal hyperplasia.
Self-check
- Which pituitary drive is reduced by CRF1 blockade in congenital adrenal hyperplasia?
ACTH. - Does CRF1 blockade correct the underlying enzyme defect?
No; it treats the axis.
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