CMV terminase inhibitor
CMV DNA terminase inhibitor
- Prevents cleavage/packaging of viral DNA into capsids
- A uniquely viral target with no human counterpart — no marrow toxicity
- No myelosuppression, unlike ganciclovir
Drugs with this mechanism (1)
- Letermovir — CMV terminase inhibitor for prophylaxis after stem cell transplant.
Self-check
- What viral-DNA processing step is stopped by CMV terminase inhibition?
Cleavage and packaging into capsids. - Which ganciclovir toxicity is absent with this mechanism?
Myelosuppression.
All mechanisms · Open CMV terminase inhibitor in the interactive console ↗