CGRP antagonist
CGRP receptor antagonist
- ↓ trigeminovascular CGRP signaling → aborts and prevents migraine
- No vasoconstriction → usable in cardiovascular disease
Drugs with this mechanism (4)
- Atogepant — Oral CGRP antagonist (gepant) for migraine prevention.
- Rimegepant — Oral CGRP antagonist (gepant) for both acute and preventive migraine.
- Ubrogepant — Oral CGRP antagonist (gepant) for acute migraine.
- Zavegepant — The first intranasal CGRP antagonist (gepant) for migraine.
Self-check
- Is CGRP-receptor blockade used to abort or prevent migraine?
Both. - What vascular distinction allows the cardiovascular use described here?
No vasoconstriction.
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