Anti-CD20 antibody

CD20-directed monoclonal antibody

Monoclonal antibody against CD20 on pre-B and mature B lymphocytes
Depletes B cells; stem cells and plasma cells are CD20-negative and are spared, so immunoglobulin production is preserved at first
Infusion reactions, hypogammaglobulinemia and infection risk; screen for hepatitis B before starting

Drugs with this mechanism (1)

Ocrelizumab — Anti-CD20 antibody — the first drug approved for primary progressive MS.

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