CB2 partial agonist
Cannabinoid CB2 receptor partial agonist
- CB2 is expressed mainly on immune and peripheral cells
- Anti-inflammatory and analgesic effects without intoxication
Drugs with this mechanism (3)
- Anandamide — The first endocannabinoid identified; a partial CB1 agonist, degraded by FAAH.
- Dronabinol — Oral delta-9-THC for chemotherapy nausea and AIDS-related anorexia; a CB1/CB2 partial agonist.
- Tetrahydrocannabinol — The cannabinoid that makes cannabis psychoactive — CB1 partial agonist.
Self-check
- Where is CB2 mainly expressed?
Immune and peripheral cells. - Do the described CB2 partial-agonist analgesic effects require intoxication?
No.
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