CB1 partial agonist

Cannabinoid CB1 receptor partial agonist

Partial agonist at CB1 receptors in the CNS — the source of the cannabis high
Partial agonism caps the ceiling effect; synthetic full agonists (K2/Spice) have no such ceiling and are far more dangerous
Dose-dependent anxiety, tachycardia and short-term memory impairment; hyperemesis with chronic heavy use

Drugs with this mechanism (1)

Tetrahydrocannabinol — The cannabinoid that makes cannabis psychoactive — CB1 partial agonist.

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