Calcitonin agonist
Calcitonin receptor agonist
- Inhibits osteoclast activity → ↓ bone resorption and serum calcium
- Tachyphylaxis with continued use
- Modest analgesia in acute vertebral fracture
Drugs with this mechanism (1)
- Calcitonin (salmon) — Salmon calcitonin for hypercalcemia and painful vertebral fracture.
Self-check
- Which bone cells are inhibited by calcitonin-receptor agonism?
Osteoclasts. - What limits the effect of continued calcitonin-receptor agonism?
Tachyphylaxis.
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