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BChE inhibitor

• Also called pseudocholinesterase (PChE) — a plasma enzyme, distinct from synaptic acetylcholinesterase
• ➔ BChE activity rises as Alzheimer disease progresses, so dual inhibition may matter more late

Drugs with this mechanism (1)

• Rivastigmine — Cholinesterase inhibitor available as a patch; also for Parkinson dementia.

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