Biotin cofactor: methylcrotonyl-CoA carboxylase (MCC)
- Required for leucine catabolism
- MCC deficiency is among the commonest findings on newborn screening
Drugs with this mechanism (1)
- Biocytin — Biotin bound to lysine; biotinidase recycles it into free biotin during protein breakdown.
Self-check
- Which amino acid requires MCC for catabolism?
Leucine. - Where is MCC deficiency commonly detected?
Newborn screening.
All mechanisms · Open Biotin cofactor: methylcrotonyl-CoA carboxylase (MCC) in the interactive console ↗