Biotin cofactor: acetyl-CoA carboxylase (ACC)
- Commits acetyl-CoA to fatty-acid synthesis (malonyl-CoA)
- Malonyl-CoA also inhibits fatty-acid entry into mitochondria — a metabolic switch
Drugs with this mechanism (1)
- Biocytin — Biotin bound to lysine; biotinidase recycles it into free biotin during protein breakdown.
Self-check
- Which product commits acetyl-CoA to fatty-acid synthesis?
Malonyl-CoA. - What mitochondrial transport does malonyl-CoA inhibit?
Fatty-acid entry.
All mechanisms · Open Biotin cofactor: acetyl-CoA carboxylase (ACC) in the interactive console ↗