Bile acid replacement
Bile acid pool replacement
- Replenishes the bile-acid pool with a hydrophilic, non-toxic bile acid
- Reduces biliary cholesterol saturation → can dissolve cholesterol gallstones
- Also cytoprotective for cholangiocytes → treats primary biliary cholangitis
Drugs with this mechanism (1)
- Ursodiol — Hydrophilic bile acid that dilutes the toxic bile acid pool.
Self-check
- Which gallstones can a hydrophilic bile acid dissolve?
Cholesterol gallstones. - Which cholestatic disease is treated through cholangiocyte protection here?
Primary biliary cholangitis.
All mechanisms · Open Bile acid replacement in the interactive console ↗