BCR-ABL/SRC inhibitor
BCR-ABL and SRC tyrosine kinase inhibitor
- Suppresses resistant CML clones that escape ABL-only inhibitors
- Pleural effusion is the signature class toxicity
Drugs with this mechanism (1)
- Dasatinib — BCR-ABL/Src inhibitor for CML; pleural effusions.
Self-check
- Which resistant CML clones can combined BCR-ABL/SRC inhibition suppress?
Clones escaping ABL-only inhibitors. - What signature toxicity is described for BCR-ABL/SRC inhibition?
Pleural effusion.
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