BCL-2 inhibitor
- Restores programmed cell death in cells addicted to anti-apoptotic BCL-2
- Deep responses in CLL and AML
- Rapid apoptosis can cause tumor lysis syndrome, mandating dose ramp-up
Drugs with this mechanism (1)
- Venetoclax — BH3 mimetic restoring apoptosis in CLL; ramp-up dosing to avoid tumor lysis.
Self-check
- What cellular process is restored by BCL-2 blockade?
Programmed cell death. - Why does BCL-2 blockade require a dose ramp-up?
Rapid apoptosis can cause tumor lysis syndrome.
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