B2 bradykinin antagonist
B2 bradykinin receptor antagonist
- ↓ bradykinin-driven vasodilation and vascular permeability → aborts hereditary angioedema attacks
- Example agent: icatibant
- Targets the same peptide that accumulates with ACE inhibitors
Drugs with this mechanism (1)
- Icatibant — Bradykinin B2 blocker for hereditary angioedema; antihistamines do not work there.
Self-check
- What attack type is aborted by bradykinin B2 blockade?
Hereditary angioedema attacks. - Which agent exemplifies bradykinin B2 blockade?
Icatibant.
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