ASIC blocker
Acid-sensing ion channel blocker
- Dampens acid-evoked pain signaling in ischemic/inflamed tissue
Drugs with this mechanism (1)
- Amiloride — ENaC-blocking potassium-sparing diuretic; treats Liddle syndrome and lithium-induced diabetes insipidus.
Self-check
- In which tissue settings does ASIC blockade dampen acid-evoked pain signaling?
Ischemic or inflamed tissue. - Which listed drug also blocks acid-sensing ion channels?
Amiloride.
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