Amylin agonist
Amylin receptor agonist
- Replaces amylin, the beta-cell co-hormone missing in diabetes
- Slows gastric emptying, suppresses glucagon and promotes satiety
- Hypoglycemia risk when combined with insulin
- Nausea
Drugs with this mechanism (1)
- Pramlintide — Amylin analog that slows gastric emptying; adjunct to mealtime insulin.
Self-check
- How does amylin agonism affect gastric emptying?
Slows it. - Which combination raises hypoglycemia risk with amylin agonism?
Insulin.
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