AMPK activator
AMP-activated protein kinase activator
- AMPK is the cellular energy sensor
- ↓ hepatic gluconeogenesis
- Shifts metabolism toward catabolism
- Promotes catabolism and ATP conservation (inhibits anabolism): ↓ hepatic glucose output, ↑ insulin sensitivity, ↓ fat accumulation, ↑ mitochondrial biogenesis
- hepatic AMPK-knockout mice still respond
Drugs with this mechanism (1)
- Salicylate — The active anti-inflammatory core of aspirin.
Self-check
- How does AMPK activation affect hepatic gluconeogenesis?
Decreases it. - Does AMPK activation favor catabolism or anabolism?
Catabolism.
All mechanisms · Open AMPK activator in the interactive console ↗