Adrenocortical cytotoxic
- ↓ steroid synthesis, especially cortisol
- The medical adrenalectomy used for adrenocortical carcinoma and refractory Cushing syndrome
- Adrenal insufficiency is expected
Drugs with this mechanism (1)
- Mitotane — Adrenolytic for adrenocortical carcinoma; months-long half-life and powerful 3A4 induction.
Self-check
- Which steroid is especially reduced by adrenocortical cytotoxic action?
Cortisol. - What endocrine deficiency is expected with adrenocortical cytotoxic therapy?
Adrenal insufficiency.
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