Adenosine A2A antagonist

Adenosine A2A receptor antagonist

Minor effect of caffeine
Enhanced wakefulness/alertness
Vasoconstriction
Pro-inflammatory effects

Drugs with this mechanism (3)

Caffeine — The world's most-used stimulant; adenosine antagonist, OTC.
Istradefylline — Adenosine A2A antagonist adjunct for Parkinson off time; a non-dopaminergic approach.
Theophylline — Old methylxanthine bronchodilator; narrow index, largely supplanted.

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