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Adenosine A1 agonist

Adenosine A1 agonist (1/2)

• Sleep promotion
• Cardiac effects
• ➔ negative chronotropy (↓ HR)
• ➔ negative dromotropy (↓ AV conduction)
• ➔ negative inotropy (↓ contractility)
• Adenosine approved for paroxysmal supraventricular tachycardia (PSVT)
• ➔ rapid IV bolus → transient AV-node block / brief asystole → terminates reentry
• Anticonvulsant effect
• Reduces glomerular filtration rate (GFR)

Adenosine A1 agonist (2/2)

• Inhibits lipolysis
• Antinociceptive effects

Drugs with this mechanism (1)

• Adenosine — Endogenous nucleoside; IV bolus terminates SVT via transient AV block.

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