5-HT4 partial agonist
5-HT4 serotonin receptor partial agonist
- Partial activation of enteric 5-HT4 → acetylcholine release and prokinesis
- Relieves constipation-predominant irritable bowel syndrome
- Partial agonism limits maximal motility stimulation
Drugs with this mechanism (1)
- Tegaserod — 5-HT4 agonist for IBS-C; withdrawn then reintroduced with restrictions.
Self-check
- Which IBS subtype is relieved by 5-HT4 partial agonism?
Constipation-predominant IBS. - How does partial agonism constrain 5-HT4-driven motility?
Limits maximal stimulation.
All mechanisms · Open 5-HT4 partial agonist in the interactive console ↗