CIPRODEX
Combination product
Pronunciation: sip-roe-FLOX-a-sin and dex-a-METH-a-soen
Combination of Ciprofloxacin and Dexamethasone.
Each component keeps its own pharmacology page; the combination itself adds no new mechanism.
Components (2)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Acute otitis media with tympanostomy tubes (S. aureus, S. pneumoniae, H. influenzae, M. catarrhalis, P. aeruginosa) | Pediatric >=6 months | 4 drops into affected ear BID | 4 drops BID | 7 days |
| Acute otitis externa (S. aureus, P. aeruginosa) | >=6 months, adults, and elderly | 4 drops into affected ear BID | 4 drops BID | 7 days |
Renal Undefined
Hepatic Undefined
Instructions
- For otic (ear) use only — not for ophthalmic use; not for injection
- Shake well immediately before use; warm bottle in hand 1–2 minutes to avoid dizziness
- Lie with affected ear upward; for AOM, pump the tragus 5 times; maintain position 60 seconds
- Discard unused portion after therapy is completed
Available strengths
- susp 0.3/0.1 %
Contraindications
- Viral infections of the external canal, including herpes simplex
Cautions
- Overgrowth of nonsusceptible organisms (yeast/fungi) with prolonged use
- Discontinue at first sign of skin rash/hypersensitivity
- Serious/fatal systemic hypersensitivity (anaphylactic) reactions reported with systemic quinolones
Adverse reactions
- Ear discomfort
- Ear pain
- Ear pruritus
- Ear debris/residue (precipitate)
Pregnancy Pregnancy Category C; animal studies with ciprofloxacin showed no teratogenicity; corticosteroids are teratogenic in animals; systemic exposure is low with otic use.
Lactation Undefined
Cost
CIPRODEX
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 0.3/0.1 % | susp | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. CIPRODEX is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
Clinical profile
Defining liabilityLocal irritation, hypersensitivity and prolonged-use microbial overgrowth
Part D rank #515.
Self-check
- Which ear-device setting is required for its listed acute otitis media use?
Tympanostomy tubes. - Which external-ear indication is also listed?
Acute otitis externa.