DUONEB
Combination product
Pronunciation: al-BYOO-ter-ol and ip-ra-TROE-pee-um (DOO-oe-neb)
Combination of Albuterol and Ipratropium.
Each component keeps its own pharmacology page; the combination itself adds no new mechanism.
Components (2)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Bronchospasm associated with COPD (requiring >1 bronchodilator) | Adults | One 3 mL vial QID via nebulizer | Up to 2 additional 3 mL doses/day if needed |
Renal Undefined
Hepatic Undefined
Instructions
- Administer via jet nebulizer with mouthpiece or face mask
Available strengths
- sol 0.083/0.017 %
- spray 100/20 mcg/inh
Contraindications
- Hypersensitivity to atropine and its derivatives
Cautions
- Paradoxical bronchospasm
- Cardiovascular effects
- Narrow-angle glaucoma / acute eye pain
- Urinary retention
- Hypersensitivity reactions
Adverse reactions
- Chest pain
- Lung disease/COPD exacerbation, pharyngitis, bronchitis
- Dyspepsia, nausea, diarrhea
- Leg cramps
- Constipation, voice alteration
Pregnancy Albuterol Pregnancy Category C (teratogenic in animals); ipratropium Category B.
Lactation Undefined
Cost
DUONEB
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 0.083/0.017 % | sol | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. DUONEB is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
Clinical profile
Defining liabilityBeta-agonist cardiovascular toxicity and peripheral antimuscarinic effects
Part D rank #226.
Self-check
- Which components make up DUONEB?
Albuterol and ipratropium. - Which COPD patients fit its listed bronchospasm indication?
Those needing a second bronchodilator.